Celebrating 15 years of GWAS discoveries

In 2022, it has been 15 years since the first well-designed genome-wide association study (GWAS). Abdel Abdellaoui and Karin Verweij from Amsterdam UMC together with Loic Yengo and Peter Visscher from the University of Queensland celebrate this with an extensive review in American Journal of Human Genetics titled “15 years of GWAS discovery: Realizing the promise”. They review how GWAS facilitated an impressive range of discoveries impacting multiple fields, including complex trait genetics, population genetics, epidemiology, social science, and medicine. They discuss a wide range of topics, including the evolution of complex traits and disease risk, increasingly predictive polygenic scores, mate choice, clinical applications such as embryo selection and gene editing, and the expansion of genomics to more global populations and rare genetic variants. Read more on 15 years since the advent of the revolutionary GWAS design here: https://authors.elsevier.com/a/1gPIVgeX2XVG

The power of sample size