Personal Page | Yuri Milaneschi, PsyD, PhD 

I studied and trained in clinical psychology and psychotherapy in Italy. Subsequently, I worked in the field of epidemiology of aging in Italy (InCHIANTI Study 2007-2010) and the USA (National Institute of Aging, 2010-2012). Due to the enriching experience in such diverse contexts, my research perspective became inherently multidisciplinary. My main research theme is the study of biological pathways that may have a role in the pathophysiology of depression, using tools of epidemiology.

At the Department of Psychiatry of Amsterdam UMC, where I am currently a researcher in psychiatry and epidemiology, I further developed the investigation of the immuno-metabolic biological pathways involved in depression. Furthermore, I embraced the exciting developments of the genomics era, expanding my skills and moving my research questions beyond the study of biomarkers of depression toward its genetic basis. I wrote invited expert reviews on genetic research in depression, the biological mechanisms connecting depression and obesity and, more recently, presenting the concept of “Immuno-Metabolic Depression”

I am currently a member of The Scientific Quality Committee (SQC) of Amsterdam Public Health and a co-PI of the new INFLAMED trial testing anti-inflammatory add-on in the treatment of Immuno-Metabolic Depression.

Yuri Milaneschi, PsyD, PhD

Department of Psychiatry, Amsterdam UMC, location VUmc

#Depression #Psychiatry #Epidemiology

Key publications

  1. de Kluiver H, Jansen R, Penninx BWJH, Giltay EJ, Schoevers RA, Milaneschi Y. Metabolomics signatures of depression: the role of symptom profiles. Transl Psychiatry. 2023 Jun 10;13(1):198.
  2. Alshehri T, Mook-Kanamori DO, de Mutsert R, Penninx BW, Rosendaal FR, le Cessie S, Milaneschi Y. The association between adiposity and atypical energy-related symptoms of depression: A role for metabolic dysregulations. Brain Behav Immun. 2023 Feb;108:197-203.
  3. Milaneschi Y, Lamers F, Berk M, Penninx BWJH. Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression. Biol Psychiatry. 2020 Sep 1;88(5):369-380.
  4. Milaneschi Y, Simmons WK, van Rossum EFC, Penninx BW. Depression and obesity: evidence of shared biological mechanisms. Mol Psychiatry. 2019 Jan;24(1):18-33.
  5. Milaneschi Y, Lamers F, Peyrot WJ, Baune BT, Breen G, Dehghan A, Forstner AJ, Grabe HJ, Homuth G, Kan C, Lewis C, Mullins N, Nauck M, Pistis G, Preisig M, Rivera M, Rietschel M, Streit F, Strohmaier J, Teumer A, Van der Auwera S, Wray NR, Boomsma DI, Penninx BWJH; CHARGE Inflammation Working Group and the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations. JAMA Psychiatry. 2017 Dec 1;74(12):1214-1225.

Grants and awards

2021 Dutch Brain Foundation. Precision Psychiatry: Anti-inflammatory medication for Immuno-Metabolic Depression (INFLAMED).

2019 ZonMW. Personalized Care for Depression: Bringing Immuno-Metabolic Depression from Bench to Bedside (PERCIM).

2011 International College of Geriatric Psychopharmacology. International Junior Investigator Award.

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