Personal Page | dr. Fiona A. Hagenbeek
Fiona Hagenbeek (1989) recently started as a postdoctoral researcher in Group Ripatti at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki. Initially, her work at FIMM will focus on exploring the gene-environment interplay of socioeconomic indicators and common diseases and disorders. She is also a visiting fellow at the Department of Biological Psychology and the Netherlands Twin Register (NTR) at the Vrije Universiteit Amsterdam where she obtained her PhD and completed her first postdoc. As part of the EU-funded ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strategies), she developed protocols for the collection of urine and buccal-cell samples in children (link). She applied these protocols in a large cohort of twin children of the NTR and obtained genome-wide SNP and DNA methylation data from the buccal cells and urinary metabolites from three targeted metabolomics platforms. With these datasets, she contributed to genetic, epigenetic, metabolomic, and multi-omic efforts to discover omics markers for aggression and related problem behaviors. Moreover, she investigated the link between genetics and metabolomics by studying the contribution of genes and environment to blood and urinary metabolite levels in adult and child populations, respectively. Besides her research, she represented the NTR in the “Connecting Data in Child Development” (CD2) project. CD2 developed a FAIR digital infrastructure that encompasses harmonized metadata of six youth cohorts in the Netherlands (link).
#Genetics #polygenic scores #epigenetics #DNA methylation #metabolomics #multi-omics #twins #externalizing behavior
Key publications
Hagenbeek, F.A., Hirzinger, J. S., Breunig, S., Bruins, S., Kuzntsov, D. V., Schut, K., Odintsova, V. V., Boomsma, D. I. (2023). Maximizing the Value of Twin Studies in Health and Behaviour. Nature Human Behaviour, 7(6), 849-860. Link
- Hagenbeek, F. A., van Dongen, J., Pool, R., Roetman, P. J., Harms, A. C., Hottenga, J. J., Kluft, C., Colins, O. F., van Beijsterveldt, C. E. M., Fanos, V., Ehli, E. A., Hankemeier, T., Vermeiren, R. R. J. M., Bartels, M., Déjean, S., & Boomsma, D. I. (2023). Integrative Multi-omics Analysis of Childhood Aggressive Behavior. Behavior Genetics, 53(2), 101-117. Link
- Hagenbeek, F. A., van Dongen, J., Pool, R., Harms, A. C., Roetman, P. J., Fanos, V., van Keulen, B. J., Walker, B. R., Karu, N., Hulshoff Pol, H. E., Rotteveel, J., Finken, M. J. J., Vermeiren, R. R. J. M., Kluft, C., Bartels, M., Hankemeier, T., & Boomsma, D. I. (2022). Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children. Metabolites, 12(6), 1-17. [474]. Link
Hagenbeek, F. A., Roetman, P. J., Pool, R., Kluft, C., Harms, A. C., van Dongen, J., Colins, O. F., Talens, S., van Beijsterveldt, C. E. M., Vandenbosch, M. M. L. J. Z., de Zeeuw, E. L., Déjean, S., Fanos, V., Ehli, E. A., Davies, G. E., Hottenga, J. J., Hankemeier, T., Bartels, M., Vermeiren, R. R. J. M., & Boomsma, D. I. (2020). Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Frontiers in Psychiatry, 11, [165]. Link
Hagenbeek, F. A., Pool, R., van Dongen, J., Draisma, H. H. M., Jan Hottenga, J., Willemsen, G., Abdellaoui, A., Fedko, I. O., den Braber, A., de Geus, E. J. C. N., Bartels, M., Nivard, M. G., Boomsma, D. I., & BBMRI Metabolomics Consortium (2020). Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nature Communications, 11(1), 1-11. [39]. Link
Grants and awards
2019: Best Presentation Award at the ACTION Consortium Meeting in Cagliari (Italy).
2019: FGB Talent Grant to support a research visit to the University of Toulouse (France).
2017: EMBL-EBI Bursary to attend the Summer School in Bioinformatics in Cambridge (UK).
2016: Behavior Genetics Association Travel Grant to attend the BGA Meeting in Brisbane (Australia).