Personal Page | Dr. Wouter J. Peyrot

Wouter Peyrot is psychiatrist and statistical genetics researcher at the Department of Psychiatry of Amsterdam UMC (location VUmc) and the Department of Complex Trait Genetics at VU University. He has a background in medicine and mathematics, and obtained his PhD (cum laude) in 2017, and was awarded with a Rubicon and Veni grant in 2018, which he combined with a postdoctoral fellowship in statistical genetics at Harvard University in America. His research aims to capitalize the great progress in genetic research to the benefit of individual patients, by developing novel genetic methods inspired by his clinical work as psychiatrist. His primary focus is on developing genetic methods to refine early clinical diagnosis in psychiatry using polygenic prediction. Other areas of experience and expertise include: genome-wide association study of case-case comparisons, the impact of assortative mating and natural selection in psychiatry, the impact of various study designs on genetic test, and gene-by-environment interaction analyses in a polygenic context. He works two days a week as clinical psychiatrist in acute psychiatric care (‘crisisdienst’).

Dr. Wouter J. Peyrot

Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam UMC, University of Amsterdam

#Psychiatric Genetics #Statistical Genetics #Cross-disorder Genetics

Key publications

  1. Peyrot WJ and Price AL. Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS. Nature Genetics 2021. PMID: 33686288. 

    Link to paper Link to software


  1. Van Rheenen W, Peyrot WJ, Schork AJ, Lee SH, Wray NR. Genetic correlations of polygenic disease traits: from theory to practice. Nature Reviews Genetics 2019. PMID: 31171865.

    Link to paper


  1. Peyrot WJ, Robinson MR, Penninx BWJH, Wray NR. Exploring boundaries for the genetic consequences of assortative mating for psychiatric traits. JAMA Psychiatry 2016. PMID: 27732705.

    Link to paper


  1. Peyrot WJ, Boomsma DI, Penninx BW, Wray NR. Disease and Polygenic Architecture: Avoid Trio Design and Appropriately Account for Unscreened Control Subjects for Common Disease. Am J Hum Genet 2016. PMID: 26849113.

    Link to paper


  1. Peyrot WJ, Van der Auwera S, Milaneschi Y, Dolan CV, PhD, Madden PAF, Sullivan PF, Strohmaier J, Ripke S, Rietschel M, Nivard MG, Mullins N, Montgomery GW, Henders AK, Heat AC, Fisher HL, Dunn EC, Byrne EM, Air TA, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Baune BT, Breen G, Levinson DF, Lewis CM, Martin NG, Nelson EN, Boomsma DI, Grabe HJ, Wray NR, Penninx BWJH. Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5,765 subjects from the Psychiatric Genomics Consortium. Biological Psychiatry 2018. PMID: 29129318.

    Link to paper

All publications

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